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KMID : 0043320110340071097
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Archives of Pharmacal Research
2011 Volume.34 No. 7 p.1097 ~ p.1105
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Constituents of the root of Anemone tomentosa
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Hu Hao Bin
Zheng Xu Dong
Jian Yu Feng
Liu Jian Xin
Zhu Ji Hua
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Abstract
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A new diterpene glycoside, tomentoside I (1), along with eleven known compounds, including the four coumarins, 4,5-dimethoxyl-7-methylcoumarin (2), 4,7-dimethoxyl-5-methylcoumarin (3), isofraxidin (4) and fraxidin (5) as well as the seven triterpenoids, oleanolic acid (6), oleanolic acid 3-O-α-L-arabinopyranoside (7), oleanolic acid 3-O-β-D-galactopyranosyl-(1→3)-β-D-glucopyranoside (8), hederagenin 3-O-α-L-arabinopyranoside (9), betulinic acid (10), 18-hydroxyursolic acid (11) and 2α,3β,23-trihydroxyurs-12-en-28-oic acid (12) were isolated from the ethanolic extract of the root of Anemone tomentosa and their chemical structures were elucidated by spectroscopic methods. The antimicrobial activities of compounds 1?12 were measured using the agar disc-diffusion method. Also, their antioxidant activities against 1,1-diphenyl-2-picrylhydrazyl (DPPH) were evaluated.
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KEYWORD
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Anemone tomentosa, Ranunculaceae, Tomentoside I, Antimicrobial activity, Antioxidant activity
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